TRIMming the response

Trimming

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TRIMming p53 for ubiquitination.

T he function of the p53 tumor suppressor protein is finely tuned through a myriad of interactions with other proteins. These interactions can lead to posttranslational modifications that regulate p53 stability, DNA binding, or promoterspecific transcriptional activation. A number of p53 binding proteins serve as cofactors that participate in the recruitment of p53 to specific promoters and fac...

Measuring the response to therapeutic foot trimming in dairy cows with fortnightly lameness scoring.

Lameness scoring (0-3) was carried out on four UK dairy farms during the housing period over three consecutive years (2010-2012). At the start of the study cows were matched by parity and stage of lactation and randomly allocated into a treatment (TX) and a control (CX) group. Cows were enrolled when two sound scores (0 or 1) were followed by a lame score (2). Farmers were immediately notified ...

Trimming the UCERF2 Hazard Logic Tree

Assessing Which Sources of Hazard Uncertainty Matter The Uniform California Earthquake Rupture Forecast 2 (UCERF2) is a fully time-dependent earthquake rupture forecast developed with sponsorship of the California Earthquake Authority (Working Group on California Earthquake Probabilities [WGCEP], 2007; Field et al., 2009). UCERF2 contains 480 logic-tree branches reflecting choices among nine mo...

TRIMming γ-actin levels improves the memory